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RO 7300490

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Drug Profile

RO 7300490

Alternative Names: Bispecific FAP-CD40 antibody; Bispecific FAP-huCD40 antibody; FAP-CD40; FAP-huCD40; Fibroblast activation Protein-α (FAP) targeted CD40 agonist; RG-6189; RO-7300490

Latest Information Update: 26 Feb 2024

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At a glance

  • Originator Roche
  • Class Antineoplastics; Bispecific antibodies; Immunotherapies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; CD40 antigen stimulants; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Solid tumours

Most Recent Events

  • 15 Feb 2024 Discontinued - Phase-I for Solid tumours (Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in Denmark (IV) (Roche pipeline, February 2024)
  • 15 Feb 2024 Discontinued - Phase-I for Solid tumours (Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in France (IV) (Roche pipeline, February 2024)
  • 15 Feb 2024 Discontinued - Phase-I for Solid tumours (Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in South Korea (IV) (Roche pipeline, February 2024)

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