Drug Profile

Obudanersen - Ionis Pharmaceuticals

Alternative Names: BIIB-121; ION-582

Latest Information Update: 18 Mar 2026

Price :

$50 ^*

Note:

Adis is an information provider. We do not sell or distribute actual drugs.
Final gross price and currency may vary according to local VAT and billing address.
Your purchase entitles you to full access to the information contained in our drug profile at the time of purchase.
A link to download a PDF version of the drug profile will be included in your email receipt.

At a glance

Originator Ionis Pharmaceuticals
Class Antisense oligonucleotides
Mechanism of Action Gene silencing; UBE3A protein expression stimulants

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

Yes - Angelman syndrome
New Molecular Entity Yes

Highest Development Phases

Phase III Angelman syndrome

Most Recent Events

02 Mar 2026 Ionis Pharmaceuticals has patent protection obudanersen in USA and Europe
09 Sep 2025 Obudanersen receives Breakthrough Therapy status for Angelman syndrome in USA
01 May 2025 Phase-III clinical trials in Angelman syndrome (In adolescents, In children, In adults) in USA (Intrathecal) (NCT06914609)

You need to be a logged in or subscribed to view this content

If your organization or you do not have a subscription, try one of the following:

Contacting your organization’s admin about adding this content to your AdisInsight subscription
Buying a PDF version of any individual profile
Request a free trial (opens in a new window)

If your organization has a subscription, there are several access options, even while working remotely:

Working within your organization’s network
Login with username/password or try to access via your institution
Persisted access using your organization’s identifier stored in your user browser for 90 days

For assistance, contact us at asktheexpert.adisinsight@springer.com