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ONCT 808

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Drug Profile

ONCT 808

Alternative Names: ONCT-808; ROR1 CAR-T cell therapy; ROR1 targeted CAR-T therapy - Oncternal Therapeutics; ROR1-CAR-T

Latest Information Update: 07 Jul 2025

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At a glance

  • Originator University of California, San Diego
  • Developer Oncternal Therapeutics, Inc.
  • Class Antineoplastics; CAR-T cell therapies; Gene therapies; Immunotherapies
  • Mechanism of Action Immunologic cytotoxicity; T lymphocyte replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Discontinued B-cell lymphoma; Solid tumours

Most Recent Events

  • 27 Jun 2025 Hoola Therapeutics acquires ONCT 808 from Oncternal Therapeutics
  • 07 Dec 2024 Efficacy, pharmacokinetics and adverse event data from a phase I/II trial in B-cell lymphoma presented at the 66th American Society of Hematology Annual Meeting and Exposition (ASH-Hem-2024)
  • 18 Sep 2024 Discontinued - Preclinical for Solid tumours in USA (Parenteral)

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