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VTX 958

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Drug Profile

VTX 958

Alternative Names: TYK2 inhibitor-Ventyx Biosciences; VTX-958

Latest Information Update: 26 Nov 2025

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At a glance

  • Originator Ventyx Biosciences
  • Class Anti-inflammatories; Antipsoriatics; Antirheumatics; Small molecules
  • Mechanism of Action TYK2 kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Crohn's disease
  • Research Autoimmune disorders
  • Discontinued Plaque psoriasis; Psoriatic arthritis

Most Recent Events

  • 07 Nov 2025 VTX 958 is available for licensing as of 07 Nov 2025. www.ventyxbio.com
  • 18 Feb 2025 Efficacy data from a phase II HARMONY trial in Crohn's disease released by Ventyx Biosciences
  • 20 Dec 2024 Ventyx Biosciences terminates the phase-II Harmony-CD trial in Crohn's disease in the US, Bulgaria, Lithuania, Slovakia, Poland, Moldova, Italy, Israel, Hungary, Germany, Georgia, Czech Republic, Canada, Brazil, Australia (PO), (NCT05688852),

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