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ALM 27134

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Drug Profile

ALM 27134

Alternative Names: ALM-27134; Anti-human IL1RAP antagonist mAb; Anti-IL-1RAP mAb - Almirall S.A; ISB-880; LAD-191

Latest Information Update: 09 Jan 2026

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At a glance

  • Originator Ichnos Sciences
  • Developer Almirall S.A.
  • Class Anti-inflammatories; Antineoplastics; Monoclonal antibodies
  • Mechanism of Action Interleukin-1 receptor accessory protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Hidradenitis suppurativa
  • Discontinued Autoimmune disorders

Most Recent Events

  • 03 Dec 2025 Discontinued - Phase-I for Autoimmune disorders in USA (SC) (Almirall S.A. Pipeline, December 2025)
  • 03 Dec 2025 Phase-II clinical trials in Hidradenitis suppurativa (Treatment-experienced) (SC) (NCT07151937)
  • 28 Nov 2025 No recent reports of development identified for phase-I development in Autoimmune-disorders in USA (Parenteral)

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