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Zongertinib - Boehringer Ingelheim

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Drug Profile

Zongertinib - Boehringer Ingelheim

Alternative Names: BI 1810631; HERNEXEOS; Hernexeos

Latest Information Update: 29 Sep 2026

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At a glance

  • Originator Boehringer Ingelheim
  • Class Amides; Antineoplastics; Benzimidazoles; Piperidines; Pyrimidines; Small molecules
  • Mechanism of Action Erb-b2 receptor tyrosine kinase antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Non-small cell lung cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Non-small cell lung cancer
  • Phase II Solid tumours
  • Phase I/II Adenocarcinoma; Colorectal cancer; HER2 positive breast cancer

Most Recent Events

  • 09 Sep 2026 Boehringer Ingelheim initiates a phase I trial in healthy volunteers in Germany (PO) (NCT07789028) (CTIS2026-525696-77-00)
  • 28 Aug 2026 No recent reports of development identified for phase-I development in Non-small-cell-lung-cancer(Inoperable/Unresectable, Late-stage disease, Metastatic disease, Monotherapy, Second-line therapy or greater) in Austria (PO, Tablet)
  • 28 Aug 2026 No recent reports of development identified for phase-I development in Non-small-cell-lung-cancer(Inoperable/Unresectable, Late-stage disease, Metastatic disease, Second-line therapy or greater) in Australia (PO, Tablet)

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