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Zongertinib - Boehringer Ingelheim

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Drug Profile

Zongertinib - Boehringer Ingelheim

Alternative Names: BI 1810631; HER2 exon 20 inhibitor

Latest Information Update: 04 Jun 2025

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At a glance

  • Originator Boehringer Ingelheim
  • Class Amides; Antineoplastics; Benzimidazoles; Piperidines; Pyrimidines; Small molecules
  • Mechanism of Action ERBB 2 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Non-small cell lung cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Preregistration Non-small cell lung cancer
  • Phase II Solid tumours
  • Phase I/II Gastric cancer; HER2 positive breast cancer; Oesophageal cancer

Most Recent Events

  • 22 May 2025 Updated efficacy and adverse events data from the phase I Beamion LUNG-1 trial in Solid tumours released by Boehringer Ingelheim
  • 28 Apr 2025 Efficacy and adverse events data from a phase Ib Beamion LUNG-1 trial in Non-small cell lung cancer released by Boehringer Ingelheim
  • 25 Apr 2025 Efficacy and adverse events data from a phase I trial Beamion LUNG-1 in Non-small cell lung cancer presented at the 116th Annual Meeting of the American Association for Cancer Research (AACR-2025)

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