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Clofutriben - Sparrow pharmaceuticals

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Drug Profile

Clofutriben - Sparrow pharmaceuticals

Alternative Names: ASP-3662; SPI-62

Latest Information Update: 23 Jan 2026

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At a glance

  • Originator Astellas Pharma
  • Developer Astellas Pharma; Sparrow Pharmaceuticals
  • Class Antihyperglycaemics; Antirheumatics; Obesity therapies; Small molecules
  • Mechanism of Action 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Cushing syndrome
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Adrenal gland disorders; Cushing syndrome; Polymyalgia rheumatica; Type 2 diabetes mellitus
  • No development reported Obesity
  • Discontinued Alzheimer's disease; Diabetic neuropathies

Most Recent Events

  • 21 Jan 2026 Discontinued - Phase-II for Diabetic neuropathies in USA (PO) (Sparrow pipeline; January 2026)
  • 31 Dec 2025 Phase-II clinical trials in Type 2 diabetes mellitus (Treatment-resistant) (PO), prior to September 2025 (NCT05436652)
  • 16 Dec 2025 Sparrow Pharmaceuticals completes a phase I pharmacokinetics trial in Healthy volunteers in USA (PO, once daily) (NCT07226635)

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