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Delpacibart zotadirsen - Avidity Biosciences

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Drug Profile

Delpacibart zotadirsen - Avidity Biosciences

Alternative Names: AOC-1044; del-zota

Latest Information Update: 17 Sep 2025

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At a glance

  • Originator Avidity Biosciences
  • Class Drug conjugates; Immunoconjugates; Monoclonal antibodies; Oligonucleotides; Small interfering RNA
  • Mechanism of Action Dystrophin expression stimulants; RNA interference
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Duchenne muscular dystrophy
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Duchenne muscular dystrophy

Most Recent Events

  • 10 Sep 2025 Pooled efficacy and safety data from the phase I/II EXPLORE44® and EXPLORE44-OLE™ trials in Duchenne muscular dystrophy released by Avidity Biosciences
  • 23 Jul 2025 Delpacibart zotadirsen - Avidity Biosciences receives Breakthrough Therapy status for Duchenne muscular dystrophy in USA
  • 27 Feb 2025 Avidity Biosciences anticipates the launch of Delpacibart zotadirsen for Duchenne muscular dystrophy ), by the year 2026

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