Drug Profile

PALI 2108

Alternative Names: GT-2108; PALI-2108

Latest Information Update: 28 Oct 2025

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At a glance

Originator Giiant Pharma
Developer Giiant Pharma; Palisade Bio
Class Anti-inflammatories; Antifibrotics; Small molecules
Mechanism of Action Type 4 cyclic nucleotide phosphodiesterase inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

Highest Development Phases

Phase I Crohn's disease; Ulcerative colitis
Preclinical Inflammatory bowel diseases

Most Recent Events

20 Oct 2025 Phase-I clinical trials in Crohn's disease in USA (PO)
13 Oct 2025 Palisade Bio has patent protection for PALI 2108 in Canada
17 Sep 2025 Updated efficacy, pharmacokinetics and adverse events data from a phase I trial in Ulcerative colitis released by Palisade Bio

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