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DFF 332

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Drug Profile

DFF 332

Alternative Names: DFF-332

Latest Information Update: 27 Mar 2026

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At a glance

  • Originator Novartis Pharmaceuticals
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Endothelial PAS domain-containing protein 1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Renal cell carcinoma

Most Recent Events

  • 27 Mar 2026 Discontinued - Phase-I for Renal cell carcinoma (Combination therapy, Inoperable/Unresectable, Late-stage disease, Metastatic disease, Second-line therapy or greater) in France, Singapore, Spain, Czech Republic, Italy, Japan, USA (PO)(Novartis Pipeline, March 2026)
  • 27 Mar 2026 Discontinued - Phase-I for Renal cell carcinoma (Inoperable/Unresectable, Late-stage disease, Metastatic disease, Monotherapy, Second-line therapy or greater) in France, Singapore, USA, Italy, Czech Republic, Spain, Japan (PO)(Novartis Pipeline, March 2026)
  • 27 Mar 2026 Discontinued - Preclinical for Renal cell carcinoma in USA (PO)(Novartis Pipeline, March 2026)

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