Drug Profile

Research programme: Ibogaine derivatives - Definium Therapeutics/Nextage Therapeutics

Latest Information Update: 22 Jan 2026

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At a glance

Originator Mindmed; Nextage Therapeutics
Developer Definium Therapeutics; Nextage Therapeutics
Class Drug withdrawal therapies; Indoles; Rauwolfia alkaloids; Small molecules
Mechanism of Action Excitatory amino acid antagonists; Nicotinic receptor antagonists; NMDA receptor agonists; Opioid receptor antagonists; Serotonin receptor antagonists

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity No

12 Jan 2026 Mindmed is now called Definium Therapeutics
28 Jun 2025 No recent reports of development identified for research development in Opioid-related-disorders in Israel
28 Jun 2025 No recent reports of development identified for research development in Opioid-related-disorders in USA

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