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Sabestomig - Astrazeneca

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Drug Profile

Sabestomig - Astrazeneca

Alternative Names: AZD-7789

Latest Information Update: 26 Feb 2025

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At a glance

  • Originator AstraZeneca
  • Class Antineoplastics; Bispecific antibodies; Immunotherapies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; HAVCR2 protein inhibitors; Programmed cell death 1 receptor antagonists; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Adenocarcinoma
  • Phase I/II Hodgkin's disease
  • Discontinued Solid tumours

Most Recent Events

  • 06 Feb 2025 Discontinued - Phase-I/II for Solid tumours (In the elderly, Late-stage disease, Metastatic disease, Second-line therapy or greater, In adults) in China, Canada, France, Japan, Netherlands, Moldova, Turkey, Georgia, Spain, USA (IV) before February 2025 (AstraZeneca pipeline, February 2025)
  • 13 Jun 2024 Efficacy, pharmacokinetics and adverse events data from a phase-I/II clinical trials in Hodgkin's disease presented at the 29th Congress of the European Haematology Association (EHA-2024)
  • 16 Apr 2024 Presage Biosciences and AstraZeneca plans a phase 0 trial for Squamous cell carcinoma (Metastatic disease, Recurrent) in USA (Intratumoural, Injection) in April 2024 (NCT06366451)

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