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VPO 227

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Drug Profile

VPO 227

Alternative Names: BPO-27; VPO-227

Latest Information Update: 18 Jul 2025

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At a glance

  • Originator University of California at San Francisco
  • Developer Vanda Pharmaceuticals
  • Class Antibacterials; Antidiarrhoeals; Carboxylic acids; Halogenated hydrocarbons; Heterocyclic compounds with 4 or more rings; Ketones; Oxazines; Pyrimidines; Pyrroles; Small molecules; Urologics
  • Mechanism of Action Cystic fibrosis transmembrane conductance regulator inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Cholera
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase I Cholera
  • No development reported Diarrhoea; Polycystic kidney disease

Most Recent Events

  • 18 Jul 2025 Phase-I clinical trials in Cholera (PO), prior to July 2025 (Vanda Pharmaceuticals pipeline, July 2025)
  • 28 Jun 2025 No recent reports of development identified for preclinical development in Diarrhoea in USA (Intraperitoneal, Injection)
  • 28 Jun 2025 No recent reports of development identified for preclinical development in Polycystic-kidney-disease in USA (Intraperitoneal, Injection)

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