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Ontunisertib - AgomAb Therapeutics

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Drug Profile

Ontunisertib - AgomAb Therapeutics

Alternative Names: AGMB-129; ORG-129

Latest Information Update: 18 Sep 2026

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At a glance

  • Originator Origo Biopharma
  • Developer AgomAb Therapeutics
  • Class Anti-inflammatories; Antifibrotics; Small molecules
  • Mechanism of Action Transforming growth factor beta type I receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Crohn's disease

Most Recent Events

  • 09 Sep 2026 Phase-I clinical trials in Crohn's disease (In volunteers) in United Kingdom (PO) (NCT07672574)
  • 24 Aug 2026 Agomab Therapeutics initiates the phase IIb NOV-ERA trial for Crohn's disease in USA (PO, Capsule) (NCT07683325)
  • 07 Aug 2026 Agomab Therapeutics plans a phase IIb NOV-ERA trial for Crohn's disease globally including US, Canada and the United Kingdom in second half of 2026

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