Drug Profile

HMPL 653

Alternative Names: HMPL-653

Latest Information Update: 20 Aug 2025

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At a glance

Originator HUTCHMED
Class Antineoplastics; Small molecules
Mechanism of Action Macrophage colony-stimulating factor receptor antagonists

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

Highest Development Phases

Phase I Giant cell tumour of tendon sheath; Solid tumours

Most Recent Events

20 Aug 2025 HMPL 653 is still in phase I development for Solid tumours and Giant-cell-tumour of the tendon sheath in China
28 Feb 2025 No recent reports of development identified for phase-I development in Giant-cell-tumour-of-tendon-sheath in China (PO)
28 Feb 2025 No recent reports of development identified for phase-I development in Solid-tumours(Late-stage disease, Metastatic disease) in China (PO)

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