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HMPL 653

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Drug Profile

HMPL 653

Alternative Names: HMPL-653

Latest Information Update: 15 Jan 2024

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At a glance

  • Originator HUTCHMED
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Macrophage colony-stimulating factor receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Giant cell tumour of tendon sheath; Solid tumours

Most Recent Events

  • 11 Oct 2023 Pharmacodynamics data from a preclinical trial in Solid tumours presented at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics (AACR-NCI-EORTC-2023)
  • 31 Dec 2022 HUTCHMED has patents pending for HMPL 653 in China, USA, Europe and Japan
  • 19 Jan 2022 Phase-I clinical trials in Giant cell tumour of tendon sheath in China (unspecified route)

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