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ESK 001

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Drug Profile

ESK 001

Alternative Names: ESK-001

Latest Information Update: 06 Sep 2024

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At a glance

  • Originator Esker Therapeutics
  • Developer Alumis
  • Class Anti-inflammatories; Antipsoriatics; Eye disorder therapies; Small molecules
  • Mechanism of Action TYK2 kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Psoriasis
  • Phase II Systemic lupus erythematosus; Uveitis
  • Preclinical Autoimmune disorders

Most Recent Events

  • 13 Aug 2024 Alumis terminates the phase-II OPTYK-1 trial in Uveitis in USA based on interim efficacy data that did not meet the Sponsor's criteria (PO), (NCT05953688),
  • 29 Jul 2024 Phase-III ONWARD clinical program in Psoriasis (PO)
  • 29 Jul 2024 Efficacy and adverse event data from a phase II OLE trials in Psoriasis released by Alumis

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