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Favezelimab/pembrolizumab - Merck Sharp & Dohme

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Drug Profile

Favezelimab/pembrolizumab - Merck Sharp & Dohme

Alternative Names: Coformulation favezelimab/pembrolizumab - Merck Sharp & Dohme; Mavezelimab/pembrolizumab - Merck Sharp & Dohme; MK 4280A; MK-4820A; Pembrolizumab/favezelimab - Merck Sharp & Dohme

Latest Information Update: 02 Mar 2026

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At a glance

  • Originator Merck Sharp & Dohme
  • Class Antineoplastics; Antivirals; Immunotherapies; Monoclonal antibodies; Tumour-agnostic therapies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; CD223 antigen inhibitors; Programmed cell death 1 receptor antagonists; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Bladder cancer; Colorectal cancer; Endometrial cancer; Hodgkin's disease; Malignant melanoma; Oesophageal cancer; Renal cell carcinoma; Small cell lung cancer; Solid tumours; Squamous cell cancer

Most Recent Events

  • 05 Dec 2025 Merck Sharp & Dohme completes phase-I/II clinical trials in Oesophageal cancer (Combination therapy, Inoperable/Unresectable, Late-stage disease, Metastatic disease, Second-line therapy or greater) in in Turkey, Thailand, Switzerland, Singapore, Norway, Germany, Chile, Brazil, Japan, South Korea, France, Italy and Taiwan(IV) (NCT05342636)
  • 06 Oct 2025 Merck Sharp & Dohme completes a phase-I/II clinical trials in Malignant melanoma (First-line therapy, Late-stage disease) in Switzerland, Italy, Israel, France, Australia, USA (IV) (NCT04303169)
  • 21 Mar 2025 Merck Sharp & Dohme completes the phase III MK-4280A-007 trial in Colorectal cancer (Metastatic disease, Inoperable/Unresectable, Second-line therapy or greater) in Australia, Canada, Chile, China, Czechia, France, Germany, Israel, Italy, Japan, Korea, Republic of, Malaysia, Norway, Russian Federation, South Africa, Spain, Taiwan, Turkey, Ukraine, the UK and US (IV) (NCT05064059)

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