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Actinium-225 DOTA TLX 592

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Drug Profile

Actinium-225 DOTA TLX 592

Alternative Names: 225Ac-DOTA-TLX 592; 225Ac-RADmAB®; 225Ac-TLX 592; TLX-592

Latest Information Update: 23 Jul 2025

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At a glance

  • Originator Telix Pharmaceuticals
  • Class Antineoplastics; Drug conjugates; Immunoconjugates; Monoclonal antibodies; Monoclonal antibody diagnostics; Radioisotopes; Radiopharmaceutical diagnostics; Radiopharmaceuticals
  • Mechanism of Action Positron-emission tomography enhancers; Radionuclide imaging enhancers
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Prostate cancer

Most Recent Events

  • 27 Mar 2025 Actinium-225 DOTA TLX 592 is still in phase I trial in Prostate cancer in Australia (Parenteral) (Telix Pharmaceuticals' pipeline, March 2025)
  • 28 Sep 2024 No recent reports of development identified for phase-I development in Prostate-cancer in Australia (Parenteral)
  • 20 May 2024 Telix Pharmaceuticals plans a phase I/II trial in Prostate cancer in the second half of 2024

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