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XmAb 808

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Drug Profile

XmAb 808

Alternative Names: B7-H3 x CD28 - Xencor; XmAb-808

Latest Information Update: 15 Aug 2026

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At a glance

  • Originator Xencor
  • Class Antineoplastics; Bispecific antibodies; Immunoglobulin Fc fragments; Immunotherapies; Recombinant fusion proteins
  • Mechanism of Action Cytotoxic T lymphocyte stimulants; Immunologic cytotoxicity
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase I Ovarian cancer; Solid tumours

Most Recent Events

  • 05 Aug 2026 Phase-I clinical trials in Ovarian cancer (Combination therapy, Late-stage disease, Metastatic disease, Recurrent) in USA (Parenteral), prior to August 2026 (NCT07593092)
  • 21 May 2026 Xencor plans a phase I trial for Solid tumours (Late stage disease, Metastatic disease, Recurrent, Combination therapy) in USA (Parenteral) in June 2026 (NCT07593092)
  • 22 Apr 2026 Pharmacodynamics data from a preclinical trial in Solid tumours presented at the 117th Annual Meeting of the American Association for Cancer Research (AACR-2026)

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