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IOV 4001

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Drug Profile

IOV 4001

Alternative Names: IOV-4001; PD-1 inactivated TIL therapy - Iovance Biotherapeutics

Latest Information Update: 16 Jun 2022

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At a glance

  • Originator Iovance Biotherapeutics
  • Class Antineoplastics; Gene therapies; Immunotherapies; T lymphocyte cell therapies; Tumour infiltrating lymphocyte therapies
  • Mechanism of Action Immunologic cytotoxicity; Lymphocyte replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No
  • Available For Licensing Yes

Highest Development Phases

  • Phase I/II Malignant melanoma; Non-small cell lung cancer

Most Recent Events

  • 20 Jul 2022 Phase-I/II clinical trials in Malignant melanoma (Inoperable/Unresectable, Metastatic disease, Late-stage disease, Second-line therapy or greater) in USA (Parenteral) (NCT05361174)
  • 20 Jul 2022 Phase-I/II clinical trials in Non-small cell lung cancer (Late-stage disease, Second-line therapy or greater) in USA (Infusion) (NCT05361174)
  • 15 Mar 2022 Iovance Biotherapeutics plans clinical trials for Malignant melanoma and Non-small cell lung cancer (Late-stage disease, Metastatic disease, Inoperable/Unresectable) in 2022

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