Drug Profile

AZD 5462

Alternative Names: AZD-5462

Latest Information Update: 30 Oct 2025

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At a glance

Originator AstraZeneca
Class Heart failure therapies; Small molecules
Mechanism of Action RXFP1 protein stimulants

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

Highest Development Phases

Phase II Heart failure

Most Recent Events

24 Sep 2025 AstraZeneca terminates a phase Ib clinical trials in Heart failure (Combination therapy, Adjunctive-treatment) in Bulgaria (PO) based on sponsor's decision (NCT06639087)
28 Jul 2025 No recent reports of development identified for phase-I development in Heart-failure(In volunteers) in USA (PO, Liquid)
14 Jul 2025 AstraZeneca terminates phase I trial in Healthy volunteers in Germany due to sponsor decision (PO) (CTIS2024-519834-21-00)

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