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ISB 1442

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Drug Profile

ISB 1442

Alternative Names: CD38 x CD47 biparatopic bispecific antibody; ISB-1442

Latest Information Update: 28 Jan 2026

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At a glance

  • Originator Ichnos Sciences
  • Class Antineoplastics; Bispecific antibodies; Immunotherapies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Multiple myeloma
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase I/II Multiple myeloma
  • No development reported Haematological malignancies

Most Recent Events

  • 28 Jan 2026 No recent reports of development identified for preclinical development in Haematological-malignancies in USA (Parenteral)
  • 07 Dec 2024 Adverse events data, pharmacokinetics and pharmacodynamics data from a phase I/II trial for Multiple myeloma presented at the 66th American Society of Hematology Annual Meeting and Exposition (ASH-Hem-2024)
  • 30 Jan 2024 Glenmark and Ichnos enters into an alliance 'Ichnos Glenmark Innovation' to accelerate drug discovery in cancer treatment

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