Drug Profile

LTP 001

Alternative Names: LTP-001

Latest Information Update: 13 Feb 2026

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At a glance

Originator Novartis
Class Antifibrotics
Mechanism of Action SMURF1 protein inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

Highest Development Phases

Phase II Idiopathic pulmonary fibrosis; Pulmonary arterial hypertension

Most Recent Events

31 Dec 2025 Novartis plans regulatory filings of LTP 001 for Pulmonary arterial hypertension on or after 2029 (Novartis pipeline, December 2025)
24 Oct 2024 Novartis Pharmaceuticals initiates a phase I/II trial for Pulmonary arterial hypertension in the US (PO) (NCT06649110)
21 Oct 2024 Novartis Pharmaceuticals plans a phase I/II trial in healthy volunteers and in Pulmonary arterial hypertension in October 2024 (PO) (NCT06649110)

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