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ARO C3

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Drug Profile

ARO C3

Alternative Names: ARO-C3

Latest Information Update: 23 Mar 2026

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At a glance

  • Originator Arrowhead Pharmaceuticals
  • Class Small interfering RNA
  • Mechanism of Action Complement C3 inhibitors; RNA interference
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II IgA nephropathy; Membranoproliferative glomerulonephritis

Most Recent Events

  • 31 Oct 2025 Arrowhead Pharmaceuticals completes the Phase-I/II clinical trials in Membranoproliferative glomerulonephritis and IgA nephropathy in Australia, Georgia, Germany, New Zealand, South Korea, Thailand, United Kingdom (SC) (NCT05083364)
  • 28 Sep 2025 No recent reports of development identified for preclinical development in Liver-disorders in USA
  • 10 Mar 2025 Interim pharmacodynamics and adverse events data from a phase I/II trial in IgA nephropathy released by Arrowhead Pharmaceuticals

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