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HG 381

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Drug Profile

HG 381

Alternative Names: HG-381

Latest Information Update: 15 Jul 2025

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At a glance

  • Originator HitGen
  • Class Antineoplastics; Small molecules
  • Mechanism of Action STING1 protein stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Solid tumours

Most Recent Events

  • 15 Jul 2025 Phase I development is ongoing in China (Hitgen pipeline, July 2025)
  • 28 Nov 2024 No recent reports of development identified for phase-I development in Solid-tumours(Late-stage disease, Monotherapy, Recurrent) in China (IV, Injection)
  • 18 Oct 2021 Phase-I clinical trials in Solid tumours (Late-stage disease, Monotherapy, Recurrent) in China (IV) (NCT04998422)

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