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SAR 443216

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Drug Profile

SAR 443216

Alternative Names: HER2/CD28xCD3 trispecific binding protein - Sanofi; SAR-443216; Trispecific antibody (CD3xCD28xHER2) - Sanofi

Latest Information Update: 20 Jul 2025

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At a glance

  • Originator Sanofi
  • Class Antineoplastics; Immunotherapies; Trispecific antibodies
  • Mechanism of Action CD28 antigen stimulants; CD3 antigen stimulants; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Discontinued Gastric cancer

Most Recent Events

  • 03 Mar 2025 Pharmacodynamics data from a phase I trial in Gastric cancer presented at the ESMO Targeted Anticancer Therapies Congress 2025 (TAT-2025)
  • 13 Sep 2024 Efficacy, adverse events and pharmacokinetics data from the phase I trial in Solid tumours presented at the 49th European Society for Medical Oncology Congress (ESMO-2024)
  • 23 Feb 2024 Discontinued - Phase-I for Gastric cancer (Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA, Spain, South Korea, Belgium, China, Taiwan, France (IV) prior to February 2024

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