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SAR 443216

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Drug Profile

SAR 443216

Alternative Names: HER2/CD28xCD3 trispecific binding protein - Sanofi; SAR-443216; Trispecific antibody (CD3xCD28xHER2) - Sanofi

Latest Information Update: 09 Jun 2024

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At a glance

  • Originator Sanofi
  • Class Antineoplastics; Immunotherapies; Trispecific antibodies
  • Mechanism of Action CD28 antigen stimulants; CD3 antigen stimulants; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Discontinued Gastric cancer

Most Recent Events

  • 23 Feb 2024 Discontinued - Phase-I for Gastric cancer (Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA, Spain, South Korea, Belgium, China, Taiwan, France (IV) prior to February 2024
  • 01 Feb 2024 Sanofi terminates a phase I trial in Gastric cancer (Late-stage disease, Metastatic disease, Second-line therapy or greater) in France, Taiwan, China, Belgium, South Korea, Spain, USA (IV) based on preliminary results
  • 25 Aug 2021 SAR 443216 is available for licensing as of 25 Aug 2021. https://www.sanofi.com/en/science-and-innovation/partnering-new/lets-partner

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