Drug Profile

AGMB 447

Alternative Names: AGMB-447; ORG-447

Latest Information Update: 14 Jan 2026

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At a glance

Originator Origo Biopharma
Developer AgomAb Therapeutics
Class Antifibrotics; Small molecules
Mechanism of Action Transforming growth factor beta type I receptor antagonists

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

Yes - Idiopathic pulmonary fibrosis
New Molecular Entity Yes

Highest Development Phases

Phase I Idiopathic pulmonary fibrosis

Most Recent Events

08 Jan 2026 Adverse events, pharmacodynamics and pharmacokinetics data from a phase I trial in Idiopathic pulmonary fibrosis released by AgomAb Therapeutics
08 Jan 2026 AgomAb Therapeutics plans a phase II trial for idiopathic pulmonary fibrosis in 2026 (Inhalation)
06 Jun 2024 AGMB 447 receives Orphan Drug status for Idiopathic pulmonary fibrosis in USA

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