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SIM 235

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Drug Profile

SIM 235

Alternative Names: SIM 0235; SIM 1811-03; SIM-235

Latest Information Update: 05 Dec 2023

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At a glance

  • Originator Simcere Pharmaceutical Group; Simcere Zaiming
  • Developer Simcere Pharmaceutical Group
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Cutaneous T-cell lymphoma; Solid tumours

Most Recent Events

  • 20 Oct 2023 Adverse events and pharmacokinetic data from a phase I trial in Cutaneous T-cell lymphoma presented at the 48th European Society for Medical Oncology Congress (ESMO-2023)
  • 14 Mar 2023 Simcere Zaiming entered into a clinical collaboration agreement with MSD to evaluate the combination of SIM 0235 and pembrolizumab
  • 30 Sep 2022 Phase-I clinical trials in Cutaneous T-cell lymphoma (Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (Parenteral) (NCT05569057)

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