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BMS 986419

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Drug Profile

BMS 986419

Alternative Names: BMS-986419; eIF2b activator - Bristol-Myers Squibb; EOAI-4018683; EVT-8683

Latest Information Update: 09 Jul 2025

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At a glance

  • Originator Evotec SE
  • Developer Bristol-Myers Squibb
  • Class Antidementias; Small molecules
  • Mechanism of Action Eukaryotic initiation factor 2b stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Alzheimer's disease; Unspecified

Most Recent Events

  • 09 Jul 2025 Phase-I clinical trials in Alzheimer's disease (unspecified route), before July 2025 (Bristol-Myers Squibb pipeline, July 2025)
  • 28 Feb 2025 No recent reports of development identified for phase-I development in Neurodegenerative-disorders in Germany (PO, Tablet)
  • 27 Feb 2025 Bristol-Myers Squibb initiates phase-I safety and pharmacokinetics trial (In volunteers) in USA (PO) (NCT06846866)

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