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Telisotuzumab adizutecan - AbbVie

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Drug Profile

Telisotuzumab adizutecan - AbbVie

Alternative Names: ABBV-400

Latest Information Update: 20 Jun 2025

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At a glance

  • Originator AbbVie
  • Class Antibodies; Antineoplastics; Drug conjugates; Immunoconjugates
  • Mechanism of Action DNA topoisomerase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Colorectal cancer
  • Phase II Adenocarcinoma
  • Phase I Solid tumours
  • No development reported Gastric cancer; Non-small cell lung cancer; Oesophageal cancer

Most Recent Events

  • 20 Jun 2025 AbbVie plans a phase II trial for Colorectal cancer (Monotherapy) in September 2025 (IV) (NCT07023289)
  • 27 May 2025 AbbVie plans a phase II/III trial for Non-small cell lung cancer (Combination therapy, First-line therapy, Inoperable/Unresectable, Late-stage disease, Metastatic disease) (IV, Infusion) in September 2025 (EudraCT2024-518586-10)(NCT07005102)
  • 26 Mar 2025 Phase-II clinical trials in Colorectal cancer (Combination therapy, Metastatic disease) in Israel (IV) (NCT06820463)

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