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EVO 756

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Drug Profile

EVO 756

Alternative Names: EVO-756; MAS-related G-protein coupled receptor X2 inhibitor - Evommune; MRGPRX2 inhibitor - Evommune

Latest Information Update: 13 Sep 2026

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At a glance

  • Originator Dermira
  • Developer Evommune
  • Class Anti-inflammatories; Antiasthmatics; Antimigraines; Antipruritics; Skin disorder therapies; Small molecules
  • Mechanism of Action MRGPRX2 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes - Pruritus

Highest Development Phases

  • Phase II Migraine
  • Discontinued Asthma; Atopic dermatitis; Chronic urticaria; Interstitial cystitis; Pruritus

Most Recent Events

  • 13 Sep 2026 Discontinued - Phase-I for Asthma (unspecified route) (Evommune pipeline, September 2026)
  • 13 Sep 2026 Discontinued - Phase-II for Atopic dermatitis in New Zealand (PO) (Evommune pipeline, September 2026)
  • 13 Sep 2026 Discontinued - Phase-II for Atopic dermatitis in USA (PO) (Evommune pipeline, September 2026)

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