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EVO 756

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Drug Profile

EVO 756

Alternative Names: EVO-756; MAS-related G-protein coupled receptor X2 inhibitor - Evommune; MRGPRX2 inhibitor - Evommune

Latest Information Update: 03 Sep 2025

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At a glance

  • Originator Dermira
  • Developer Evommune
  • Class Antiasthmatics; Antipruritics; Skin disorder therapies; Small molecules
  • Mechanism of Action MRGPRX2 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes - Pruritus

Highest Development Phases

  • Phase II Atopic dermatitis; Chronic urticaria
  • Phase I Asthma
  • Preclinical Pruritus
  • Discontinued Interstitial cystitis

Most Recent Events

  • 03 Sep 2025 Phase-II clinical trials in Atopic dermatitis in USA (PO)
  • 28 May 2025 Efficacy and adverse events data from a phase II trial in Chronic urticaria released by Evommune
  • 08 May 2025 Evommune completes phase II clinical trials in Chronic-urticaria in USA (PO) (NCT06603220)

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