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EVO 756

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Drug Profile

EVO 756

Alternative Names: EVO-756; MAS-related G-protein coupled receptor X2 inhibitor - Evommune; MRGPRX2 inhibitor - Evommune

Latest Information Update: 05 Jun 2025

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At a glance

  • Originator Dermira
  • Developer Evommune
  • Class Antiasthmatics; Antipruritics; Skin disorder therapies; Small molecules
  • Mechanism of Action MRGPRX2 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes - Pruritus

Highest Development Phases

  • Phase II Chronic urticaria
  • Phase I Asthma; Atopic dermatitis
  • Preclinical Pruritus
  • Discontinued Interstitial cystitis

Most Recent Events

  • 28 May 2025 Efficacy and adverse events data from a phase II trial in Chronic urticaria released by Evommune
  • 20 Apr 2025 Evommune initiates a phase IIb trial for Chronic-urticaria in USA (PO) (NCT06873516)
  • 15 Apr 2025 Evommune plans a phase IIb trial for Atopic dermatitis (PO), in 2025

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