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5-Methoxy 2-aminoindane - Clearmind Medicine

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Drug Profile

5-Methoxy 2-aminoindane - Clearmind Medicine

Alternative Names: 5-MeO-AI - Clearmind Medicine; CMND-100; MEAI - Clearmind Medicine

Latest Information Update: 22 Dec 2025

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At a glance

  • Originator Clearmind Medicine
  • Developer Clearmind Medicine; SciSparc
  • Class Amines; Antipsychotics; Drug withdrawal therapies; Ethers; Indans; Obesity therapies
  • Mechanism of Action 5-HT1A serotonin receptor modulators; Serotonin 5-HT2A receptor modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Alcoholism
  • Preclinical Cocaine-related disorders; Metabolic syndrome; Obesity

Most Recent Events

  • 16 Dec 2025 Efficacy data from a phase I/IIa trial in Alcoholism released by Clearmind Medicine
  • 24 Nov 2025 Clearmind Medicine’s Data and Safety Monitoring Board unanimously approved the continuation of the phase I/IIa clinical trial for CMND 100 following a positive interim safety review
  • 18 Nov 2025 Top-line efficacy data from a phase I/IIa trial in Alcoholism released by Clearmind Medicine

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