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Calderasib - Merck Sharp & Dohme Corp.

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Drug Profile

Calderasib - Merck Sharp & Dohme Corp.

Alternative Names: MK-1084

Latest Information Update: 04 Nov 2025

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At a glance

  • Originator Merck Sharp & Dohme Corp.
  • Class Alkanes; Alkenes; Antineoplastics; Chlorinated hydrocarbons; Cyclic ethers; Fluorobenzenes; Heterocyclic compounds with 4 or more rings; Ketones; Piperazines; Pyridines; Pyrimidinones; Small molecules
  • Mechanism of Action KRAS protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Adenocarcinoma; Non-small cell lung cancer
  • No development reported Solid tumours

Most Recent Events

  • 29 Oct 2025 Merck Sharp & Dohme LLC plans a phase I (MK-1084-016) pharmacokinetics trial (In volunteers, Combination therapy) in November 2025 (PO) (NCT07222098)
  • 27 Oct 2025 Merck Sharp & Dohme plans a phase I Pharmacokinetics trial (In volunteers) (PO) in November 2025 (NCT07219550)
  • 08 Oct 2025 Phase-III clinical trials in Non-small cell lung cancer (Combination therapy, Late-stage disease, Metastatic disease, First-line therapy) in Taiwan, Taiwan, Ukraine, USA (PO) (NCT07190248)

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