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MK 1084

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Drug Profile

MK 1084

Alternative Names: MK-1084

Latest Information Update: 08 Jun 2025

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At a glance

  • Originator Merck Sharp & Dohme Corp.
  • Class Antineoplastics; Small molecules
  • Mechanism of Action KRAS protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Non-small cell lung cancer
  • No development reported Solid tumours

Most Recent Events

  • 08 Jun 2025 Phase I development is ongoing in Non-small cell lung cancer (Combination therapy, First-line therapy) in Israel, Panama, Poland, Switzerland and Taiwan (PO) (NCT05067283)
  • 30 May 2025 Efficacy and adverse events data from the phase I KANDLELIT-001 trial in Solid tumors released by Merck Sharp & Dohme
  • 30 May 2025 Merck Sharp & Dohme plans a phase III KANDLELIT-012 trial for Colorectal Cancer (Combination therapy, Inoperable/Unresectable, First-line therapy or greater, Metastatic disease, Late-stage disease) in July 2025 (PO) (NCT06997497)

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