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Enlicitide decanoate - Merck Sharp & Dohme

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Drug Profile

Enlicitide decanoate - Merck Sharp & Dohme

Alternative Names: Enlicitide Chloride; MK-0616

Latest Information Update: 20 Oct 2025

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At a glance

  • Originator Merck Sharp & Dohme Corp.
  • Class Antihyperlipidaemics; Cyclic peptides; Urologics
  • Mechanism of Action PCSK9 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Hypercholesterolaemia; Hyperlipoproteinaemia type IIa

Most Recent Events

  • 14 Oct 2025 Merck Sharp & Dohme plans a phase III trial for Hypercholesterolaemia (PO), in November 2025 (NCT07216482) (EUCT2025-521495-54-00)
  • 02 Sep 2025 Topline efficacy and adverse events data from the phase III CORALreef Lipids trial in Hypercholesterolaemia released by Merck Sharp & Dohme Corp.
  • 02 Sep 2025 Merck Sharp & Dohme completes enrolment in the phase III CORALreef Outcomes trial in Hypercholesterolaemia (Treatment-experienced) in USA, Argentina, Australia, Taiwan, Brazil, Canada, China, Chile, Colombia, Denmark, France, Germany, Hong Kong, Hungary, Israel, Italy, Japan, Mexico, Netherlands, New Zealand, Norway, Peru, Poland, Puerto Rico, South Africa, South Korea, Spain, Turkey, and United Kingdom (PO), prior to September 2025 (NCT06008756)

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