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PF 07260437

Drug Profile

PF 07260437

Alternative Names: B7-H4; B7-H4 x CD3 bi-specific mAb - Pfizer; PF-07260437

Latest Information Update: 23 Nov 2023

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At a glance

  • Originator Pfizer
  • Class Antineoplastics; Bispecific antibodies; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; T lymphocyte stimulants; V-set domain-containing T-cell activation inhibitor 1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Solid tumours

Most Recent Events

  • 09 Nov 2023 Discontinued - Phase-I for Solid tumours (Late-stage disease, Metastatic disease) in Puerto Rico (Parenteral) (NCT05067972)
  • 09 Nov 2023 Discontinued - Phase-I for Solid tumours (Late-stage disease, Metastatic disease) in USA (Parenteral) (NCT05067972)
  • 09 Nov 2023 Pfizer terminates a phase I trial in Solid tumours (Late-stage disease, Metastatic disease) in USA and Puerto Rico (Parenteral) based on internal discontinue further development of PF 07260437 (NCT05067972)

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