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XL 114

Drug Profile

XL 114

Alternative Names: AUR 104; XL-114

Latest Information Update: 28 May 2025

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At a glance

  • Originator Aurigene Discovery Technologies
  • Developer Aurigene Oncology
  • Class Antineoplastics; Small molecules
  • Mechanism of Action MALT1 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Solid tumours
  • No development reported Non-Hodgkin's lymphoma

Most Recent Events

  • 28 May 2025 No recent reports of development identified for phase-I development in Non-Hodgkin's-lymphoma(Second-line therapy or greater) in USA (PO, Tablet)
  • 19 Jul 2023 Exelixis terminates a phase I trial in Non-Hodgkin's lymphoma (Second-line therapy or greater) in USA (PO) due to sponsor reasons (NCT05144347)
  • 12 Apr 2022 Phase-I clinical trials in Non-Hodgkin's lymphoma (Second-line therapy or greater) in USA (PO) (NCT05144347)

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