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APB R3

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Drug Profile

APB R3

Alternative Names: APB-R3; EVO-301; Long-acting IL-18BP; Long-acting interleukin-18 binding protein

Latest Information Update: 14 Oct 2025

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At a glance

  • Originator APRILBIO
  • Developer APRILBIO; Evommune
  • Class Anti-inflammatories; Antirheumatics; Fab fragments; Proteins; Recombinant fusion proteins; Skin disorder therapies
  • Mechanism of Action Interleukin 18 replacements; Interleukin-18 binding protein replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Atopic dermatitis
  • Phase I Adult-onset Still's disease; Ulcerative colitis
  • Preclinical Liver disorders

Most Recent Events

  • 14 Oct 2025 Phase-I clinical trials in Ulcerative colitis (unspecified route), prior to October 2025 (Evommune pipeline, October 2025)
  • 13 Feb 2025 Phase-II clinical trials in Atopic dermatitis in Australia, New Zealand (IV) (NCT06723405)
  • 09 Dec 2024 Evommune plans a phase II trial for Atopic dermatitis in Australia, New Zealand (IV) (NCT06723405)

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