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AK 127

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Drug Profile

AK 127

Alternative Names: AK-127

Latest Information Update: 26 Mar 2026

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At a glance

  • Originator Akeso Biopharma
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; Natural killer cell stimulants; T lymphocyte stimulants; TIGIT protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Liver cancer
  • Phase I Solid tumours

Most Recent Events

  • 26 Mar 2026 AK 127 is still in phase I trials for Solid tumours (Metastatic disease, Combination therapy, Late-stage disease, Second-line therapy or greater) in Australia (IV) (NCT05021120)
  • 01 Apr 2025 Akesobio completes a phase I clinical trials in Solid tumours (Metastatic disease, Combination therapy, Late-stage disease, Second-line therapy or greater) in Australia (IV) (NCT05021120)
  • 28 Nov 2024 No recent reports of development identified for phase-I development in Solid-tumours(Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in Australia (IV, Infusion)

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