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A2B 530

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Drug Profile

A2B 530

Alternative Names: A2B-530; Autologous logic-gated Tmod™ CAR T-cell therapy - A2 Biotherapeutics; Tmod CAR T-cell Therapy - A2 Biotherapeutics

Latest Information Update: 23 Sep 2025

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At a glance

  • Originator A2 Biotherapeutics
  • Class Antineoplastics; CAR-T cell therapies; Gene therapies; Immunotherapies
  • Mechanism of Action Immunologic cytotoxicity; T lymphocyte replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Colorectal cancer
  • New Molecular Entity No

Highest Development Phases

  • Phase I/II Colorectal cancer; Non-small cell lung cancer; Pancreatic cancer; Solid tumours

Most Recent Events

  • 30 May 2025 Efficacy and adverse event data from a phase I/II EVEREST-1 trial presented at the 61st Annual Meeting of the American Society of Clinical Oncology (ASCO-2025)
  • 09 Nov 2024 Efficacy, adverse event and pharmacokinetics data from the phase I/II EVEREST-1 trial released by A2 Biotherapeutics
  • 04 Mar 2024 A2B 530 receives Orphan Drug status for Colorectal cancer in USA

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