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Tagarafdeg - C4 Therapeutics

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Drug Profile

Tagarafdeg - C4 Therapeutics

Alternative Names: CFT-1946

Latest Information Update: 26 Jun 2026

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At a glance

  • Originator C4 Therapeutics
  • Class Amines; Antineoplastics; Aza compounds; Ethers; Fluorinated hydrocarbons; Indazoles; Ketones; Nitriles; Piperidines; Pyrimidines; Quinazolines; Small molecules; Spiro compounds
  • Mechanism of Action Proto-oncogene protein b-raf degraders
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase I/II Malignant melanoma; Solid tumours

Most Recent Events

  • 26 Jun 2026 C4 Therapeutics completes the Phase-I/II clinical trials in Malignant melanoma and Solid tumours (Late-stage disease, Metastatic disease, Combination therapy, Monotherapy, Second-line therapy or greater) in USA, Germany, Spain, France and United Kingdom (PO)(NCT05668585)
  • 07 May 2025 Tagarafdeg is available for licensing as of 07 May 2025. https://ir.c4therapeutics.com/contact-ir
  • 20 Jan 2025 Chemical structure information added.

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