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Dabogratinib - TYRA Biosciences

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Drug Profile

Dabogratinib - TYRA Biosciences

Alternative Names: TYRA-300; TYRA-300-B01

Latest Information Update: 01 Sep 2025

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At a glance

  • Originator Tyra Biosciences
  • Class Antineoplastics; Chlorinated hydrocarbons; Ethers; Indazoles; Pyridines; Small molecules; Spiro compounds; Sulfones
  • Mechanism of Action Type 3 fibroblast growth factor receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Achondroplasia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Achondroplasia; Bladder cancer
  • Phase I/II Solid tumours
  • Preclinical Hypochondroplasia

Most Recent Events

  • 21 Aug 2025 Tyra Biosciences plans a Clinical trial for Urogenital cancer (Metastatic disease) (PO)
  • 12 Jul 2025 Pharmacodynamics data from a preclinical trial in Achondroplasia presented at the 107th Annual Meeting of the Endocrine Society (ENDO-2025)
  • 05 Jun 2025 Phase-II clinical trials in Bladder cancer in USA (PO) (NCT06995677)

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