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MRT 2359

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Drug Profile

MRT 2359

Alternative Names: MRT-2359

Latest Information Update: 22 Dec 2025

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At a glance

  • Originator Monte Rosa Therapeutics
  • Class Antineoplastics; Carbamates; Ethers; Fluorobenzenes; Isoindoles; Ketones; Piperidines; Small molecules
  • Mechanism of Action Peptide-chain-release factor 3 degraders
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Small cell lung cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Diffuse large B cell lymphoma; HER2 negative breast cancer; HER2 positive breast cancer; Neuroendocrine tumours; Non-small cell lung cancer; Prostate cancer; Small cell lung cancer; Solid tumours

Most Recent Events

  • 16 Dec 2025 Interim adverse events and efficacy data from a phase I/II trial in Solid tumours released by Monte Rosa Therapeutics (ADNM)
  • 16 Dec 2025 Monte Rosa Therapeutics plans a phase II trial for Prostate cancer (Hormone-refractory, Metastatic disease, Combination therapy) in 2026
  • 31 Mar 2025 Updated efficacy data from a phase I/II trial in Solid tumours released by Monte Rosa Therapeutics

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