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MRT 2359

Drug Profile

MRT 2359

Alternative Names: MRT-2359

Latest Information Update: 10 Jan 2024

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At a glance

  • Originator Monte Rosa Therapeutics
  • Class Antineoplastics; Carbamates; Ethers; Fluorobenzenes; Isoindoles; Ketones; Piperidines; Small molecules
  • Mechanism of Action Peptide-chain-release factor 3 degraders
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Small cell lung cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Diffuse large B cell lymphoma; Neuroendocrine tumours; Non-small cell lung cancer; Small cell lung cancer; Solid tumours

Most Recent Events

  • 08 Jan 2024 MRT 2359 receives Fast Track designation for Small cell lung cancer [PO] (Late-stage disease, Second-line therapy or greater, Metastatic disease) in USA
  • 03 Nov 2023 Chemical structure information added
  • 17 Oct 2023 Interim efficacy, adverse events and pharmacodynamics data from a phase I/II trial in Neuroendocrine tumours, Non-small cell lung cancer, Small cell lung cancer, Solid tumours and Lymphoma released by Monte Rosa Therapeutics
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