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Puxitatug samrotecan - AstraZeneca

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Drug Profile

Puxitatug samrotecan - AstraZeneca

Alternative Names: AZD-8205; Puxi-Sam - AstraZeneca

Latest Information Update: 06 Aug 2026

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At a glance

  • Originator AstraZeneca
  • Class Antibodies; Antineoplastics; Drug conjugates; Immunoconjugates
  • Mechanism of Action DNA topoisomerase I inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Endometrial cancer
  • Phase II Adenoid cystic carcinoma
  • Phase I/II Solid tumours

Most Recent Events

  • 02 Jul 2026 Efficacy and adverse events data from a phase I/II trial in Solid tumours presented at the 62nd Annual Meeting of the American Society of Clinical Oncology (ASCO-2026)
  • 29 May 2026 Efficacy and adverse events data from a phase I/II trial in Solid tumours presented at the 62nd Annual Meeting of the American Society of Clinical Oncology (ASCO-2026)
  • 22 May 2026 Puxitatug samrotecan - AstraZeneca receives Breakthrough Therapy status for Solid tumours (Metastatic disease, Late-stage disease, Recurrent, Second-line therapy or greater) in USA

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