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Denosumab biosimilar - Alvotech

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Drug Profile

Denosumab biosimilar - Alvotech

Alternative Names: Acvybra; AVT-03-Alvotech; AVT03; Kefdensis; Xbonzy; Zvogra

Latest Information Update: 01 Dec 2025

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At a glance

  • Originator Alvotech
  • Class Antihypercalcaemics; Antineoplastics; Antirheumatics; Calcium regulators; Immunotherapies; Monoclonal antibodies; Osteoporosis therapies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; RANK ligand inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Registered Bone disorders; Corticosteroid-induced osteoporosis; Postmenopausal osteoporosis
  • Preregistration Giant cell tumour of bone; Osteoporosis

Most Recent Events

  • 24 Nov 2025 Registered for Bone disorders (Prevention) in European Union (SC)
  • 24 Nov 2025 Registered for Corticosteroid-induced osteoporosis in European Union (SC)
  • 24 Nov 2025 Registered for Postmenopausal osteoporosis in European Union (SC)

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